Back to Peter Lehmann Publishing
Testimony from July 18, 2001 to: New York State Assembly Committee on Mental Health Mental Retardation & Developmental Disabilities Albany, New York
Peter Sterling, Ph.D.
Written Testimony to the New York State Assembly
As a neuroscientist I have studied the structure and function of the mammalian brain for more than 30 years. I teach this subject to medical and graduate students at the University of Pennsylvania where I also conduct an active research program on this subject. I became concerned about the effects of electroconvulsive shock (ECS) on the brain more than 25 years ago after reading in the New Yorker magazine about Marilyn Rice, a bright, professional woman whose memory was destroyed by a series of "therapeutic" ECS treatments. This led me to study the literature on ECS, both the clinical literature regarding possible efficacy and negative side-effects and also the experimental literaturethe application of ECS to animals in order to study the basis for the possible efficacy and side effects. I have continued to follow this literature over several decades and here summarize my main conclusions.ECS unquestionably damages the brain. The damage is due to a variety of known mechanisms:
The degree of damage consequent to ECS varies between individuals. It can be catastrophic in response to a single series, as for Marily Rice and Ann Donohue (see below), or it can appear more gradually following repeated series. This is much like the damage to boxerswho may occasionally die in the ring due to massive cerebral hemorrhage, or more commonly accumulate damage until the impairment becomes obvious. Since any positive therapeutic effect of ECS is temporary, the treatment is commonly repeated, so chronic brain damage is inevitable.
The key manifestation of this damage is memory loss. This is disturbing enough, but there are probably other losses as well, such as the ability to think clearly, to learn new facts, and so on. It must be particularly incapacitating to individuals who are already impaired by a mental illness. So, one would expect physicians to weigh carefully the possible benefits of the therapy against the cumulative damage that it causes. However, rather than weigh gain vs. loss, psychiatrists deny the obvious, that there is cumulative damage.
The reason that psychiatrists can remain unaware of accumulating memory loss is that they do not routinely test for it. Testing is required when patients take certain drugs, such as lithium. High blood levels of lithium can be toxic; and lithium can damage the blood-forming cells in the bone marrow. Therefore, blood levels of the drug and the state of the bone marrow are monitored. Memory loss could be monitored just as easilyby asking patients before ECS about early events in their lives and then questioning the patients following each series of ECS. When this was done by Janis (almost 50 years ago), losses were marked and prolonged. However, no systematic effort has been made since then to do this simple test.
The current literature completely supports these points. For example, a recent editorial by Harold Sackheim (proponent of the practice) in the Journal of ECT (Vol. 16, pp 87-96, 2000) thoroughly summarizes recent evidence of the significant memory loss due to ECS. And the article in the same issue by a patient Ann Donohue (pp. 133-143) provides one more poignant description, very much like Marilyn Rice's, of her crippling loss following her ECS.
Finally, a controlled study just published by Sackheim and colleagues (JAMA 285:1299-1307 2001) reports that of patients with major, drug resistant depression (i.e., the main candidates for ECS), nearly 40% fail to respond to the treatment. Thus, they are subjected to the brain damage and memory loss without the benefit. Furthermore, the study documents a high rate of relapse within six months of stopping ECS. Even with the most efficacious drug therapy, the relapse rate was still high. So this supports the point that the benefit is only temporary and tends to lead to accumulation of more ECS and more brain damage.
The physician's first injunction is "Do no harm." Because this treatment clearly does harm, I believe it to be misguided. Where the treatment is applied without investigating the degree of harm and monitoring its accumulation, I believe it to be irresponsible and therefore requiring of regulation.
Peter Sterling, Ph.D.